High-Fat Diet Impacts on Tumor Development in the Gut.

Milou S van Driel, Sanne M van Neerven, Louis Vermeulen

Journal: Trends in cancer 2021;7(8):664-665

PMID: 34219052

Free Full Text on Elsevier Science View on PubMed

Abstract

A high-fat diet (HFD) directly acts on intestinal stem cells by increasing their numbers and proliferation, resulting in an elevated risk of developing colorectal cancer (CRC). In a recent study, Mana et al. revealed that HFD-mediated intestinal tumor formation can be reduced by inhibiting fatty acid oxidation.

Address: Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology and Metabolism, Amsterdam University Medical Centers, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands; Oncode Institute, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology and Metabolism, Amsterdam University Medical Centers, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands; Oncode Institute, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. Electronic address: [email protected].

DOI: 10.1016/j.trecan.2021.06.005

Link outs

Free resources

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S2405...

Medical:

https://medlineplus.gov/colorectalcancer.html

MeSH Terms: Colorectal Neoplasms, Diet, High-Fat, Gastrointestinal Microbiome, Humans, Lipid Metabolism