20 years of Hepcidin: How far we have come.

Silvia Colucci, Oriana Marques, Sandro Altamura

Journal: Seminars in hematology 2022;58(3):132-144

PMID: 34389105

Full Text on Elsevier Science View on PubMed

Abstract

Twenty years ago the discovery of hepcidin deeply changed our understanding of the regulation of systemic iron homeostasis. It is now clear that hepcidin orchestrates systemic iron levels by controlling the amount of iron exported into the bloodstream through ferroportin. Hepcidin expression is increased in situations where systemic iron levels should be reduced, such as in iron overload and infection. Conversely, hepcidin is repressed during iron deficiency, hypoxia or expanded erythropoiesis, to increase systemic iron availability and sustain erythropoiesis. In this review, we will focus on molecular mechanisms of hepcidin regulation and on the pathological consequences of their disruption.

Address: Department of Pediatric Hematology, Oncology and Immunology - University of Heidelberg, Heidelberg, Germany.; Molecular Medicine Partnership Unit, EMBL and University of Heidelberg, Heidelberg, Germany.; Department of Pediatric Hematology, Oncology and Immunology - University of Heidelberg, Heidelberg, Germany.; Molecular Medicine Partnership Unit, EMBL and University of Heidelberg, Heidelberg, Germany.. Electronic address: [email protected].

DOI: 10.1053/j.seminhematol.2021.05.001

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MeSH Terms: Erythropoiesis, Hepcidins, Homeostasis, Humans, Iron, Iron Overload