The effects of beraprost sodium on renal function and cardiometabolic profile in patients with diabetes mellitus: a systematic review and meta-analysis of clinical trials.

Peyman Nowrouzi-Sohrabi, Reza Tabrizi, Kamran Hessami, Mojtaba Shabani-Borujeni, Mahnaz Hosseini-Bensenjan, Shahla Rezaei, Mohammad Jalali, Pedram Keshavarz, Fariba Ahmadizar

Journal: International urology and nephrology 2022;54(1):111-120

PMID: 34019221

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Abstract

PURPOSE

This systematic review and meta-analysis aimed to assess renal function and cardiometabolic biomarkers after treatment with beraprost sodium in patients with diabetes mellitus.

METHODS

We systemically searched PubMed, Embase, Scopus, Web of Science, and Cochrane Library up to August 2020. Statistical heterogeneities were computed using Cochrane's Q test and I test. A fixed- or random-effects model was used to calculate the weighted mean difference (WMD) and corresponding 95% confidence intervals (CI).

RESULTS

From 341citations, seven trials were included into our meta-analysis. Our findings demonstrated that beraprost sodium intake significantly decreased blood urea nitrogen (BUN) (WMD = -5.62, 95% CI [-8.49, -2.74], P < 0.001) and cystatin C (WMD = -0.57, 95% CI [-0.68, -0.46], P < 0.001). Beraprost sodium intake had no significant effect on fasting blood sugar (FBS), hemoglobin A1c (HbA1c), cholesterol (TC), triglycerides (TG), HDL-C, LDL-C, systolic blood pressure (SBP), diastolic blood pressure (DBP), and creatinine (Cr) in patients with diabetes receiving beraprost sodium in comparison with the controls.

CONCLUSION

Our meta-analysis revealed that beraprost sodium administration significantly decreased BUN and cystatin C levels in patients with diabetes. However, no significant effect was observed on the cardiometabolic profile.

Address: Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.; Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran. [email protected].; Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran. [email protected].; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.; Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.; Faculty of Pharmacy, Department of Clinical Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.; Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.; Nutrition Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.; Nutrition Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.; Department of Radiology, Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.; Department of Epidemiology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.

DOI: 10.1007/s11255-021-02887-7