Salivary biomarkers of stress and inflammation in first graders in Côte d'Ivoire: Effects of a probiotic food intervention.

Bonnie E Brett, Bruno K Koko, Habib O Y Doumbia, Frédéric Kouadio Koffi, Savorgnan E Assa, Kollet Y A S Zahé, Hortense Faye-Ketté, Séraphin Kati-Coulibaly, Remco Kort, Wilbert Sybesma, Gregor Reid, Carolina de Weerth

Journal: Psychoneuroendocrinology 2022;129():105255

PMID: 34020263

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Abstract

This semi-randomized controlled trial examined the effects of a probiotic food supplement on cortisol and C-reactive protein (CRP) in a sample of 262 four-to seven-year-old children (56% girls) in two economically-disadvantaged schools in an urban setting in Côte d'Ivoire. For one semester, children in one school were randomized to receive a probiotic (N = 79) or placebo (N = 85) fermented dairy food each day they attended school; one child (due to medical reasons) and all children in the other school (N = 98) continued their diets as usual. Children provided two saliva samples at 11:30 on consecutive days at the end of the study. Analyses revealed that the probiotic group had lower cortisol than the placebo or diet-as-usual groups (p = .015); CRP levels were comparable across groups (p = .549). Exploratory analyses suggested that dose and regularity of consumption may impact the biomarkers as well. This study provides the first evidence that a probiotic milk product may lower cortisol in a sample of young, economically-disadvantaged children.

Address: Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Radboud University Medical Center, P.O. Box 9010, 6500 GL Nijmegen, The Netherlands. Electronic address: [email protected].; UFR Biosciences, Université Félix Houghouët-Boigny, 01 BP V34 Abidjan, Côte d'Ivoire. Electronic address: [email protected].; UFR Biosciences, Université Félix Houghouët-Boigny, 01 BP V34 Abidjan, Côte d'Ivoire. Electronic address: [email protected].; UFR Biosciences, Université Félix Houghouët-Boigny, 01 BP V34 Abidjan, Côte d'Ivoire. Electronic address: [email protected].; UFR Biosciences, Université Félix Houghouët-Boigny, 01 BP V34 Abidjan, Côte d'Ivoire. Electronic address: [email protected].; UFR Biosciences, Université Félix Houghouët-Boigny, 01 BP V34 Abidjan, Côte d'Ivoire. Electronic address: [email protected].; UFR Biosciences, Université Félix Houghouët-Boigny, 01 BP V34 Abidjan, Côte d'Ivoire; Institut Pasteur de Côte d'Ivoire, Abidjan, Cocody, CHU, Côte d'Ivoire. Electronic address: [email protected].; UFR Biosciences, Université Félix Houghouët-Boigny, 01 BP V34 Abidjan, Côte d'Ivoire; Institut Pasteur de Côte d'Ivoire, Abidjan, Cocody, CHU, Côte d'Ivoire. Electronic address: [email protected].; Yoba For Life Foundation, Hunzestraat 133-A, 1079 WB Amsterdam, The Netherlands; Department of Molecular Cell Biology, Vrije Universiteit Amsterdam, De Boelelaan 1105, 1081 HV Amsterdam, The Netherlands. Electronic address: [email protected].; Yoba For Life Foundation, Hunzestraat 133-A, 1079 WB Amsterdam, The Netherlands. Electronic address: [email protected].; Lawson Health Research Institute and Western University, 268 Grosvenor St, London, ON N6A 4V2, Canada. Electronic address: [email protected].; Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Radboud University Medical Center, P.O. Box 9010, 6500 GL Nijmegen, The Netherlands. Electronic address: [email protected].

DOI: 10.1016/j.psyneuen.2021.105255

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MeSH Terms: Biomarkers, C-Reactive Protein, Child, Child, Preschool, Cote d'Ivoire, Female, Humans, Hydrocortisone, Inflammation, Male, Poverty, Probiotics, Saliva, Stress, Psychological, Students