Leptomeningeal involvement in a patient with splenic lymphoma with villous lymphocytes.

Vladimir Gotlib, Sanjay Singareddy, Usam Gergis, John Vakios, Elizabeth Guevara, Amy Chadburn, Leonid L Yavorkovsky, Arun Patel, Ahmar Butt, Asha Nayak

Journal: Leukemia & lymphoma 2003;43(6):1337-40

PMID: 12153005

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Abstract

Splenic lymphoma with villous lymphocytes (SLVL) is an indolent hematological malignancy. Persistent lymphocytosis and splenomegaly usually last for years before patients develop infectious complications. Organ involvement other than spleen and bone marrow is rare in SLVL. We report a case of SLVL-related meningitis occurring in a patient presenting with altered mental status and seizures. CNS involvement was documented by an MRI of the head and by the presence of atypical lymphocytes in the cerebrospinal fluid (CSF). Morphologic examination and immunophenotypic analyses were conducted to determine the nature of atypical lymphocytes in the peripheral blood, spleen, bone marrow and CSF. The patient improved after treatment with a combination of radiation and chemotherapy.

Address: Division of Hematology/Oncology, The Brooklyn Hospital Center, New York 11201, USA. [email protected]

DOI: 10.1080/10428190290026411

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MeSH Terms: Aged, Antineoplastic Combined Chemotherapy Protocols, Cerebrospinal Fluid, Cranial Irradiation, Cyclophosphamide, Dexamethasone, Erythrocyte Transfusion, Humans, Lymphocytosis, Lymphoma, Non-Hodgkin, Magnetic Resonance Imaging, Male, Meninges, Neoplastic Stem Cells, Prednisone, Splenic Neoplasms, Vincristine, Vitamin B 12, Vitamin B 12 Deficiency