Triggers of Exacerbation in Chronic Urticaria and Recurrent Angioedema-Prevalence and Relevance.

Anete Sevciovic Grumach, Petra Staubach-Renz, Ricardo Cardona Villa, Susana Diez-Zuluaga, Imke Reese, William R Lumry

Journal: The journal of allergy and clinical immunology. In practice 2021;9(6):2160-2168

PMID: 34112472

Full Text on Elsevier Science View on PubMed

Abstract

Patients with urticaria and angioedema often have triggers that cause an outbreak or a swelling episode or worsen their chronic condition. Exploring these factors with each patient may result in better understanding and control of their disease. Patients should be advised to avoid known triggers, if feasible, or prepare to prevent or control an exacerbation with appropriate pretreatment if avoidance is not possible. In this review, we describe and discuss a variety of factors for which there is evidence that they cause or exacerbate chronic spontaneous urticaria and angioedema. These potentially exacerbating factors include drugs, food additives, and naturally occurring pseudoallergens, mental stress, and trauma.

Address: Faculdade de Medicina, Centro Universitario Saude ABC, Santo Andre, Sao Paulo, Brazil.; Department of Dermatology, University Medical Center, Mainz, Germany.; Facultad de Medicina-Universidad de Antioquia, Grupo de Alergología Clínica y Experimental, Medellín, Colombia.; Dietary Counseling and Nutrition Therapy Centre, Munich, Germany.; Clinical Faculty, University of Texas Southwestern Medical School, Allergy and Asthma Specialists, Dallas, Texas. Electronic address: [email protected].

DOI: 10.1016/j.jaip.2021.04.023

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MeSH Terms: Angioedema, Chronic Disease, Chronic Urticaria, Humans, Prevalence, Urticaria