Developmental Origins of Health and Disease (DOHaD): The importance of life-course and transgenerational approaches.

Erika Hagemann, Desiree T Silva, Jacqueline A Davis, Lisa Y Gibson, Susan L Prescott

Journal: Paediatric respiratory reviews 2021;40():3-9

PMID: 34148804

Full Text on Elsevier Science View on PubMed

Abstract

With well-established evidence that early life conditions have a profound influence on lifespan and health-span, new interventional birth cohorts are examining ways to optimise health potential of individuals and communities. These are aimed at going beyond preventing disease, to the conditions that facilitate flourishing from an early age. Covering diverse domains, local community projects, such as The ORIGINS Project, are taking a broader approach to the protective and buffering factors that enhance resilience and reduce allostatic load, such as building nature relatedness, interpersonal relationships, mindfulness, and positive emotions. Such cohorts aim to address how 'upstream' approaches will have flow on effects to the 'historical' risk targets (such as poor nutrition, physical inactivity, and stress) by influencing these core behaviours through better relationships with self, community, and the environment. In addition to scientific pursuit, interventional cohorts can contribute to solutions ineverycommunity - nourishing individuals and communities towards positive change.

Address: Telethon Kids Institute, Northern Entrance, Perth Children's Hospital, 15 Hospital Avenue, Nedlands WA 6009, PO Box 855, West Perth, WA 6872, Australia; Edith Cowan University, 270 Joondalup Dr, Joondalup, WA 6027, Australia. Electronic address: [email protected].; Telethon Kids Institute, Northern Entrance, Perth Children's Hospital, 15 Hospital Avenue, Nedlands WA 6009, PO Box 855, West Perth, WA 6872, Australia; The University of Western Australia, 35 Stirling Hwy, Crawley, WA 6009, Australia; Joondalup Health Campus, Suite 210 Specialist Centre, 60 Shenton Avenue, Joondalup WA 6027, Australia; Edith Cowan University, 270 Joondalup Dr, Joondalup, WA 6027, Australia.; Telethon Kids Institute, Northern Entrance, Perth Children's Hospital, 15 Hospital Avenue, Nedlands WA 6009, PO Box 855, West Perth, WA 6872, Australia; The University of Western Australia, 35 Stirling Hwy, Crawley, WA 6009, Australia.; Telethon Kids Institute, Northern Entrance, Perth Children's Hospital, 15 Hospital Avenue, Nedlands WA 6009, PO Box 855, West Perth, WA 6872, Australia; The University of Western Australia, 35 Stirling Hwy, Crawley, WA 6009, Australia; Edith Cowan University, 270 Joondalup Dr, Joondalup, WA 6027, Australia.; Telethon Kids Institute, Northern Entrance, Perth Children's Hospital, 15 Hospital Avenue, Nedlands WA 6009, PO Box 855, West Perth, WA 6872, Australia; The University of Western Australia, 35 Stirling Hwy, Crawley, WA 6009, Australia; Joondalup Health Campus, Suite 210 Specialist Centre, 60 Shenton Avenue, Joondalup WA 6027, Australia; Edith Cowan University, 270 Joondalup Dr, Joondalup, WA 6027, Australia; inVIVO Planetary Health of the Worldwide Universities Network (WUN), West New York, NJ, United States.

DOI: 10.1016/j.prrv.2021.05.005

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MeSH Terms: Health Status, Humans, Malnutrition