Current Therapies for Alcohol-Associated Hepatitis.

Haripriya Maddur

Journal: Clinics in liver disease 2021;25(3):595-602

PMID: 34229842

Full Text on Elsevier Science View on PubMed

Abstract

Alcohol-associated hepatitis is associated with poor outcomes, especially when severe. Despite extensive study with a plethora of potential therapeutic agents, treatment options remain limited, with the current standard of therapy being corticosteroids. Granulocyte colony-stimulating factor is an alternate agent that seems promising, although further study in a more heterogenous patient population is needed before implementation. Adjuncts to therapy that are often overlooked are alcohol abstinence and adequate optimization of nutrition to improve outcomes. In select patients, early liver transplantation may be an option or enrollment in clinical trials.

Address: Department of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, 676 North Street Clair, Suite 1900, Chicago, IL 60611, USA. Electronic address: [email protected].

DOI: 10.1016/j.cld.2021.03.005

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MeSH Terms: Adrenal Cortex Hormones, Granulocyte Colony-Stimulating Factor, Hepatitis, Alcoholic, Humans, Liver Transplantation, Pentoxifylline