A Tour of TOR Complex Signaling in Plants.

Graham M Burkart, Federica Brandizzi

Journal: Trends in biochemical sciences 2021;46(5):417-428

PMID: 33309324

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Abstract

To identify the appropriate times for growth and development, organisms must sense and process information about the availability of nutrients, energy status, and environmental cues. For sessile eukaryotes such as plants, integrating such information can be critical in life or death decisions. For nearly 30 years, the conserved phosphatidylinositol 3-kinase-related protein kinases (PIKKs) target of rapamycin (TOR) has been established as a central hub for integrating external and internal metabolic cues. Despite the functional conservation across eukaryotes, the TOR complex has evolved specific functional and mechanistic features in plants. Here, we present recent findings on the plant TOR complex that highlight the conserved and unique nature of this critical growth regulator and its role in multiple aspects of plant life.

Address: MSU-DOE Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA.; MSU-DOE Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA; Department of Plant Biology, Michigan State University, East Lansing, MI 48824, USA; Great Lakes Bioenergy Research Center, Michigan State University, East Lansing, MI 48824, USA. Electronic address: [email protected].

DOI: 10.1016/j.tibs.2020.11.004

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MeSH Terms: Plants, Signal Transduction, Sirolimus, TOR Serine-Threonine Kinases