Inflammaging and the Skin.

Suzanne M Pilkington, Silvia Bulfone-Paus, Christopher E M Griffiths, Rachel E B Watson

Journal: The Journal of investigative dermatology 2021;141(4S):1087-1095

PMID: 33358020

Free Full Text on Elsevier Science View on PubMed

Abstract

As global life expectancy continues to rise, we are challenged with maintaining health into old age. One strategy is to target the chronic low-level inflammation associated with aging, termed inflammaging. This is characterized by increased levels of circulating proinflammatory cytokines and a shift toward cellular senescence, changes that are believed to drive many age-associated conditions, including dementia, arthritis, and type 2 diabetes. As with other organs, the skin undergoes functional decline during aging, becoming more fragile and susceptible to infection; however, the contribution of inflammaging is not well-understood. This review article describes the evidence for inflammaging in the skin, its relationship with senescence, and how this relates to declining skin structure and function.

Address: Centre for Dermatology Research, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom; Lydia Becker Institute of Immunology and Inflammation, The University of Manchester, Manchester, United Kingdom; Manchester Institute for Collaborative Research on Aging, The University of Manchester, Manchester, United Kingdom. Electronic address: [email protected].; Centre for Dermatology Research, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom; Lydia Becker Institute of Immunology and Inflammation, The University of Manchester, Manchester, United Kingdom; NIHR Manchester Biomedical Research Centre, The University of Manchester, Manchester, United Kingdom.; Centre for Dermatology Research, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom; Lydia Becker Institute of Immunology and Inflammation, The University of Manchester, Manchester, United Kingdom; Manchester Institute for Collaborative Research on Aging, The University of Manchester, Manchester, United Kingdom; NIHR Manchester Biomedical Research Centre, The University of Manchester, Manchester, United Kingdom.

DOI: 10.1016/j.jid.2020.11.006

Link outs

Free resources

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0022...

Medical:

https://medlineplus.gov/skinaging.html

Other Literature Sources:

https://scite.ai/reports/33358020

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-HLA-B-1

MeSH Terms: Cellular Senescence, Cytokines, Fibroblasts, Healthy Aging, Humans, Immunosenescence, Inflammation, Keratinocytes, Langerhans Cells, Skin, Skin Aging, T-Lymphocytes