Challenge to overcome current limitations of cell-penetrating peptides.

Gyu Chan Kim, Dae Hee Cheon, Yan Lee

Journal: Biochimica et biophysica acta. Proteins and proteomics 2021;1869(4):140604

PMID: 33453413

Full Text on Elsevier Science View on PubMed

Abstract

The penetration of biological membranes is a prime obstacle for the delivery of pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver various cargos across the biological membranes. Since the discovery, CPPs have been rigorously studied to unveil the underlying penetrating mechanism as well as to exploit CPPs for various biomedical applications. This review will focus on the various strategies to overcome current limitations regarding stability, selectivity, and efficacy of CPPs.

Address: Department of Chemistry, Seoul National University, Seoul 151-742, Republic of Korea.; Department of Chemistry, Seoul National University, Seoul 151-742, Republic of Korea. Electronic address: [email protected].

DOI: 10.1016/j.bbapap.2021.140604

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MeSH Terms: Amino Acid Sequence, Cell Membrane, Cell-Penetrating Peptides, Drug Delivery Systems, Humans, Pore Forming Cytotoxic Proteins