2D Nanomaterials for Tissue Engineering and Regenerative Nanomedicines: Recent Advances and Future Challenges.

Yuanyuan Zheng, Xiangqian Hong, Jiantao Wang, Longbao Feng, Taojian Fan, Rui Guo, Han Zhang

Journal: Advanced healthcare materials 2021;10(7):e2001743

PMID: 33511775

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Abstract

Regenerative medicine has become one of the hottest research topics in medical science that provides a promising way for repairing tissue defects in the human body. Due to their excellent physicochemical properties, the application of 2D nanomaterials in regenerative medicine has gradually developed and has been attracting a wide range of research interests in recent years. In particular, graphene and its derivatives, black phosphorus, and transition metal dichalcogenides are applied in all the aspects of tissue engineering to replace or restore tissues. This review focuses on the latest advances in the application of 2D-nanomaterial-based hydrogels, nanosheets, or scaffolds that are engineered to repair skin, bone, and cartilage tissues. Reviews on other applications, including cardiac muscle regeneration, skeletal muscle repair, nerve regeneration, brain disease treatment, and spinal cord healing are also provided. The challenges and prospects of applications of 2D nanomaterials in regenerative medicine are discussed.

Address: Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Guangdong Provincial Engineering and Technological Research Center for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, P. R. China.; Shenzhen Eye Institute, Shenzhen Eye Hospital Affiliated to Jinan University, School of Optometry, Shenzhen University, Shenzhen, 518040, P. R. China.; Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, P. R. China.

DOI: 10.1002/adhm.202001743

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MeSH Terms: Graphite, Humans, Nanomedicine, Nanostructures, Regenerative Medicine, Tissue Engineering