Synthetic Enzyme-Catalyzed CO Fixation Reactions.

Godwin A Aleku, George W Roberts, Gabriel R Titchiner, David Leys

Journal: ChemSusChem 2021;14(8):1781-1804

PMID: 33631048

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Abstract

In recent years, (de)carboxylases that catalyze reversible (de)carboxylation have been targeted for application as carboxylation catalysts. This has led to the development of proof-of-concept (bio)synthetic CO fixation routes for chemical production. However, further progress towards industrial application has been hampered by the thermodynamic constraint that accompanies fixing CO to organic molecules. In this Review, biocatalytic carboxylation methods are discussed with emphases on the diverse strategies devised to alleviate the inherent thermodynamic constraints and their application in synthetic CO -fixation cascades.

Address: Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK.; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.

DOI: 10.1002/cssc.202100159

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MeSH Terms: Biocatalysis, Biotin, Carbon Dioxide, Carboxy-Lyases, Dinitrocresols, Metals, Molecular Structure, Pyridoxal, Structure-Activity Relationship, Thermodynamics, Thiamine Pyrophosphate