Cyrus Ayubcha, Mateen Moghbel, Austin J Borja, Andrew Newberg, Thomas J Werner, Abass Alavi, Mona-Elisabeth Revheim
Journal: PET clinics 2021;16(2):249-260
PMID: 33648666
Tau proteins play a significant role in a variety of degenerative neurologic conditions. Postmortem neuropathology studies of victims of repeat and severe head trauma have defined a unique spatial expression of neurologic tauopathies in these individuals, known as chronic traumatic encephalopathy. Established and newly developed radiotracers are now being applied to head injury populations with the intent of diagnosis and disease monitoring. This review assesses the role of tau in head injury, the state of tau radiotracer development, and the potential clinical value of tau-PET as derived from head injury studies.
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
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