Development and characterization of self-etching adhesives doped with 45S5 and niobophosphate bioactive glasses: Physicochemical, mechanical, bioactivity and interface properties.

Edilausson Moreno Carvalho, Paulo Vitor Campos Ferreira, Mario Felipe Gutiérrez, Ruan Ferreira Sampaio, Ceci Nunes Carvalho, Alan Silva de Menezes, Alessandro Dourado Loguercio, José Bauer

Journal: Dental materials : official publication of the Academy of Dental Materials 2021;37(6):1030-1045

PMID: 33846019

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Abstract

OBJECTIVE

The aim of study was to develop and characterize experimental bioactive glasses (45S5 and niobophosphate bioactive glass (NbG)) and evaluate the effects of their addition in self-etching adhesive systems on physicochemical, mechanical, and bioactive properties, microtensile bond strength (μTBS), and nanoleakage (NL).

METHODS

Two-step self-etching adhesive systems containing 5, 10, and 20 wt.% of 45S5 and NbG bioactive glasses were developed. An experimental adhesive without microparticles and a commercial adhesive (Clearfil SE Bond) were used as control groups. The materials were evaluated for their degree of conversion (DC%), ultimate tensile strength (UTS), softening in solvent, radiopacity, sorption and solubility, alkalizing activity (pH), ionic release, and bioactivity. μTBS and NL were evaluated after 24 h and 1 year of storage. The data were subjected to analysis of variance and post-Holm-Sidak tests (α = 0.05).

RESULTS

The addition of the two bioactive glasses did not change the values of the degree of conversion, ultimate tensile strength, and softening in solvent. The adhesive system containing 20% NbG showed the highest radiopacity. The incorporation of 45S5 increased water sorption and solubility, raised the pH, and allowed the release of large amounts of calcium. After 28 days of immersion in simulated body fluid, the 45S5 adhesive precipitated hydroxyapatite and calcium carbonate (SEM/EDX, ATR/FTIR, and XDR). The addition of 45S5 and NbG to the adhesives improved the stability of the resin-dentin interface after 1 year.

SIGNIFICANCE

The incorporation of microparticles from 45S5 bioactive glass in self-etching adhesive systems is considered an excellent alternative for the development of a bioactive adhesive that improves the integrity of the hybrid layer on sound dentin.

Address: University Ceuma (UNICEUMA), School of Dentistry, R. Josué Montello, 1, Renascença II, 65075-120 São Luis, Maranhão, Brazil. Electronic address: [email protected].; Department of Restorative Dentistry, Dental Materials Division, School of Dentistry, University of Campinas (UNICAMP), Av. Limeira, 901, 13414-903 Piracicaba, São Paulo, Brazil. Electronic address: [email protected].; Department of Biomaterials, School of Dentistry, Universidad de los Andes, Av. Monseñor Álvaro del Portillo 12455, 7550000 Las Condes, Santiago, Chile; Institute for Research in Dental Sciences, Faculty of Dentistry, University of Chile, Av. Olivos 943, 8380544 Independencia, Santiago, Chile. Electronic address: [email protected].; University Ceuma (UNICEUMA), School of Dentistry, R. Josué Montello, 1, Renascença II, 65075-120 São Luis, Maranhão, Brazil. Electronic address: [email protected].; University Ceuma (UNICEUMA), School of Dentistry, R. Josué Montello, 1, Renascença II, 65075-120 São Luis, Maranhão, Brazil. Electronic address: [email protected].; Department of Physics, Federal University of Maranhão (UFMA), Av. dos Portugueses, 1966, 65080-805 São Luís, Maranhão, Brazil. Electronic address: [email protected].; Department of Restorative Dentistry, School of Dentistry, State University of Ponta Grossa (UEPG), Rua Carlos Cavalcanti, 4748, Campus Uvaranas, 84030-900 Ponta Grossa, Paraná, Brazil. Electronic address: [email protected].; Discipline of Dental Materials, School of Dentistry, Federal University of Maranhão (UFMA), Av. dos Portugueses, 1966, 65080-805 São Luís, Maranhão, Brazil. Electronic address: [email protected].

DOI: 10.1016/j.dental.2021.03.004

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MeSH Terms: Dental Bonding, Dental Cements, Dentin, Materials Testing, Tensile Strength