Roles and mechanisms of phospholipid transfer protein in the development of Alzheimer's disease.

Hao Wang, Mei-Hua Chen, Wei Chen, Ji-Guo Zhang, Shu-Cun Qin

Journal: Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 2021;21(4):659-667

PMID: 33851473

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Abstract

Phospholipid transfer protein (PLTP) is a complex glycosylated protein that mediates the transfer of phospholipids, unesterified cholesterol, diacylglycerides, specific apolipoproteins, and tocopherols between different classes of lipoproteins as well as between lipoproteins and cells. Many studies have associated PLTP with a variety of lipid metabolic diseases. However, recent studies have indicated that PLTP is highly expressed in the brain of vertebrate and may be related to many central nervous system diseases, such as Alzheimer's disease. Here, we review the data and report the role and mechanisms PLTP in Alzheimer's disease.

Address: Institute of Pharmacology, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, China.; Key Laboratory of Atherosclerosis in Universities of Shandong; Institute of Atherosclerosis, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, China.

DOI: 10.1111/psyg.12685