Novel 2,5-Diarylcyclopentenone Derivatives from the Wild Edible Mushroom and Their Antioxidant Activities.

Wild edible mushrooms are important as a source of nutraceuticals and for the discovery of bioactive metabolites as pharmaceuticals. In this work, 10 rare 2,5-diarylcyclopentenone derivatives were isolated from the wild edible mushroom (Batsch) Fr., including eight novel compounds termed involutenone A-H () and two previously identified compounds (). Their structures were established using high-resolution electrospray ionization mass spectroscopy and 1D and 2D nuclear magnetic resonance data. The absolute configurations of compounds and were assigned based on the comparison of the experimental and calculated electronic circular dichroism data. The antioxidant activities of were tested through DPPH free radical scavenging, hydroxyl radical scavenging, and superoxide anion radical scavenging assays. Compounds , , , and demonstrated significant antioxidant activity compared to the positive control (-butylhydroquinone). These compounds could be effective natural antioxidants with considerable pharmaceutical value.