Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities.

Jesalyn Bolduc, Katarina Koruza, Ting Luo, Julia Malo Pueyo, Trung Nghia Vo, Daria Ezeriņa, Joris Messens

Journal: Redox biology 2021;42():101959

PMID: 33895094

Free Full Text on Elsevier Science View on PubMed

Abstract

Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein interactions. Understanding the role of the multiple structural and post-translational modification (PTM) layers that tunes the peroxiredoxin specificities is still a challenge. In this review, we give a tabulated overview on what is known about human and bacterial peroxiredoxins with a focus on structure, PTMs, and protein-protein interactions. Armed with numerous cellular and atomic level experimental techniques, we look at the future and ask ourselves what is still needed to give us a clearer view on the cellular operating power of Prdxs in both stress and non-stress conditions.

Address: VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie, B-1050, Brussels, Belgium; Brussels Center for Redox Biology, Vrije Universiteit Brussel, B-1050, Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, B-1050, Brussels, Belgium.; VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie, B-1050, Brussels, Belgium; Brussels Center for Redox Biology, Vrije Universiteit Brussel, B-1050, Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, B-1050, Brussels, Belgium. Electronic address: [email protected].

DOI: 10.1016/j.redox.2021.101959

Link outs

Free resources

Full Text Sources:

Other Literature Sources:

https://scite.ai/reports/33895094

Miscellaneous:

https://assays.cancer.gov/CPTAC-1532

MeSH Terms: Humans, Hydrogen Peroxide, Oxidation-Reduction, Peroxides, Peroxiredoxins, Personality, Signal Transduction