Xiao-Jun Li, Si-Qi Tang, Hao Huang, Jiao Luo, Xiao-Dan Zhang, Chang-Soo Yook, Wan-Kyunn Whang, Youn-Chul Kim, Xiang-Qian Liu
Journal: Molecules (Basel, Switzerland) 2021;26(8):2215
PMID: 33921386
(Oliv.) Harms (Araliaceae), also known as and () in Chinese, is a widely used traditional Chinese herb with the effects of expelling wind and removing dampness, relaxing the muscles and stimulating the blood circulation, and regulating the flow of to alleviate pain in the theory of Traditional Chinese Medicine. (AH, thereafter) possesses ginseng-like activities and is known as ginseng-like herb. In the past decade, a great number of phytochemical and pharmacological studies on AH have been carried out. Several kinds of chemical compositions have been reported, including terpenoids (monoterpenoids, diterpenoids, and triterpenoid saponins), phenylpropanoids, caffeoyl quinic acid derivatives, flavonoids, lignans, sterols, fatty acids, etc., among which, triterpenoid saponins were considered to be the most active components. Considerable pharmacological experiments in vitro have demonstrated that AH possessed anti-neuroinflammatory, anti-adipogenic, anti-inflammatory, antibacterial, anti-cancer, anti-oxidation, anti-AChE, anti-BuChE, and antihyaluronidase activities. The present review is an up-to-date and comprehensive analysis of the botany, phytochemistry, and pharmacology of AH.
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