Glucocorticoids in adipocytes stimulate visceral obesity.

George Wolf

Journal: Nutrition reviews 2002;60(5 Pt 1):148-51

PMID: 12030279

Full Text on Silverchair Information Systems View on PubMed

Abstract

The enzyme 11beta hydroxysteroid dehydrogenase-1 (11beta HSD-1) regenerates active glucocorticoids from inactive glucocorticoids. When over-expressed in adipose tissue, this enzyme was shown to promote increased visceral adipose levels. The resulting visceral obesity was associated with insulin-resistant diabetes and dyslipidemia. Increased adipocyte 11beta HSD-1 is a possible cause of visceral obesity in humans.

Address: Department of Nutritional Sciences and Toxicology, University of California, Berkeley 94720-3104, USA.

DOI: 10.1301/00296640260093823

Link outs

Free resources

Medical:

https://medlineplus.gov/obesity.html

Subscription / membership required

Full Text Sources:

https://academic.oup.com/nutritionreviews/article-...

MeSH Terms: 11-beta-Hydroxysteroid Dehydrogenase Type 1, Abdomen, Adipocytes, Adipose Tissue, Body Composition, Glucocorticoids, Humans, Hydroxysteroid Dehydrogenases, Metabolic Syndrome, Obesity, Structure-Activity Relationship, Viscera, Weight Gain