The protective roles of clusterin in ocular diseases caused by obesity and diabetes mellitus type 2.

Thaís Dantis Pereira de Campos, Kellen Cristina da Cruz Rodrigues, Rodrigo Martins Pereira, Chadi Pellegrini Anaruma, Raphael Dos Santos Canciglieri, Diego Gomes de Melo, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, Eduardo Rochete Ropelle, José Rodrigo Pauli, Leandro Pereira de Moura

Journal: Molecular biology reports 2021;48(5):4637-4645

PMID: 34036481

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Abstract

Obesity is a chronic, non-transmissible and multifactorial disease commonly associated with systemic inflammation and damage to health. This disorder has been pointed out as leading to the development of a diversity of eye diseases and, consequently, damage to visual acuity. More specifically, cardiometabolic risk is associated with lacrimal gland dysfunctions, since it changes the inflammatory profile favoring the development and worsening of dry eye disease. In more severe and extreme cases, obesity, inflammation, and diabetes mellitus type 2 can trigger the total loss of vision. In this scenario, besides its numerous metabolic functions, clusterin, an apolipoprotein, has been described as protective to the ocular surface through the seal mechanism. Thus, the current review aimed to explain the role of clusterin in dry eye disease that can be triggered by obesity and diabetes.

Address: Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, 1300 Pedro Zaccaria Street, Limeira, SP, Brazil.; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.; Laboratory of Nutritional Genomics (LABGeN), School of Applied Sciences, University of Campinas, Limeira, SP, Brazil.; CEPECE - Center of Research in Sport Sciences. School of Applied Sciences, University of Campinas (UNICAMP), Limeira, SP, Brazil.; Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, 1300 Pedro Zaccaria Street, Limeira, SP, Brazil. [email protected].; CEPECE - Center of Research in Sport Sciences. School of Applied Sciences, University of Campinas (UNICAMP), Limeira, SP, Brazil. [email protected].; Postgraduate Program in Motricity Sciences, São Paulo State University (UNESP), São Paulo, Brazil. [email protected].

DOI: 10.1007/s11033-021-06419-5