Expression, regulation and function of Aquaporin-3 in colonic epithelial cells.

Jonathan Yde, Stephen J Keely, Hanne B Moeller

Journal: Biochimica et biophysica acta. Biomembranes 2021;1863(7):183619

PMID: 33811845

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Abstract

The human colon balances water and electrolyte absorption and secretion while also forming a barrier protecting the body from the entry of harmful components. Aquaporin-3 (AQP3) is a water, glycerol and HO transporting channel expressed in colonic epithelia. Although expression of colonic epithelial AQP3 is altered in several intestinal disorders, such as inflammatory bowel disease and irritable bowel syndrome, the regulation and specific roles of AQP3 remain to be fully defined. In this mini-review, we summarize the current understanding of the expression, regulation, and biological functions of AQP3 protein in colonic epithelia concerning intestinal absorption, secretion and barrier function.

Address: Department of Biomedicine, Aarhus University, Aarhus DK-8000, Denmark.; Molecular Medicine Laboratories, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.; Department of Biomedicine, Aarhus University, Aarhus DK-8000, Denmark. Electronic address: [email protected].

DOI: 10.1016/j.bbamem.2021.183619

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MeSH Terms: Aquaporin 3, Colon, Epithelial Cells, Gene Expression Regulation, Humans, Hydrogen Peroxide, Inflammatory Bowel Diseases, Models, Biological, Water