Epigenetic loss of m1A RNA demethylase ALKBH3 in Hodgkin lymphoma targets collagen, conferring poor clinical outcome.

Address: Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain.; Department of Pathology, Bellvitge Biomedical Research Institute (IDIBELL), Hospital Universitari de Bellvitge, Universitat de Barcelona, L'Hospitalet, Barcelona, Spain.; Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain.; Centro de Investigación Biomédica en Red (CIBER) de Cáncer (CIBERONC), Madrid, Spain.; Clinical Hematology Department, Catalan Institute of Oncology (ICO), Hospital Duran i Reynals, L'Hospitalet, Barcelona, Spain.; Department of Pathology, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP) and.; Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain.; Department of Hematology, Catalan Institute of Oncology (ICO), Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain.; Apheresis and Cellular Therapy Unit, Department of Hemotherapy and Hemostasis (ICMHO), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain.; Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.; Laboratory of Experimental Pathology (LAPEX), Gonçalo Moniz Research Center, Oswaldo Cruz Foundation (CPQGM/FIOCRUZ), Salvador, Brazil.; Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.; Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain.; CIBER de Bioingeniería Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain.; Biomedical Research Institute Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Nanomaterials and Nanotechnology Research Center-Spanish National Research Council (CINN-CSIC).; Health Research Institute of Asturias (ISPA).; Institute of Oncology of Asturias (IUOPA), and.; Department of Organisms and Systems Biology (B.O.S), University of Oviedo, Oviedo, Spain.; Centro de Investigación Biomédica en Red (CIBER) de Cáncer (CIBERONC), Madrid, Spain.; Service of Pathology, Fundación Jiménez Díaz University Hospital, Madrid, Spain.; Cancer Research Center and.; Wohl Institute for Translational Medicine, Chaim Sheba Medical Center, Tel-Hashomer, Israel.; Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain.; Centro de Investigación Biomédica en Red (CIBER) de Cáncer (CIBERONC), Madrid, Spain.; Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain; and.; Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB), Barcelona, Spain.