Updated clinical evidence and place in therapy of bempedoic acid for hypercholesterolemia: ANMCO position paper.

Nadia Aspromonte, Domenico Gabrielli, Michele Massimo Gulizia, Andrea Di Lenarda, Fortunato Scotto di Uccio, Massimo Imazio, Giuseppina Maura Francese, Stefano Domenicucci, Manlio Cipriani, Furio Colivicchi, Vincenzo Amodeo, Loris Roncon, Stefano Urbinati, Serafina Valente, Adriano Murrone, Pasquale Caldarola, Pietro Scicchitano, Stefania Angela Di Fusco

Journal: Journal of cardiovascular medicine (Hagerstown, Md.) 2021;22(3):162-171

PMID: 32842050

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Abstract

The central role of high low-density lipoprotein cholesterol levels in atherosclerotic cardiovascular disease has led to research focused on lipid-lowering agents for cardiovascular risk reduction. Bempedoic acid is an emerging treatment for hypercholesterolemia that has recently been approved for marketing in the United States and Europe. This review focuses on its mechanism of action and summarizes the main preclinical study findings. Furthermore, we report the clinical evidence supporting and guiding its use in hypercholesterolemia management.

Address: Clinical and Rehabilitative Cardiology Unit, San Filippo Neri Hospital ASL Roma 1, Rome.; U.O.C. Cardiologia-UTIC, San Paolo Hospital, Bari.; Section of Cardiovascular Diseases, Department of Emergency and Organ Transplantation, School of Medicine, University of Bari, Bari.; Cardilogy-Intensive Care Unit, Ospedali di Città di Castello e Gubbio - Gualdo Tadino, Azienda USL Umbria 1, Perugia.; Cardiology Department, Le Scotte University Hospital, Siena.; Cardiology Unit, Bellaria Hospital, AUSL of Bologna, Bologna.; Cardiology Unit, Ospedale Santa Maria della Misericordia, Rovigo.; Cardiology-Intensive Care Unit, Santa Maria degli Ungheresi Hospital, Polistena, Reggio Calabria.; Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome.; Cardiology Unit 2, ASST Grande Ospedale Metropolitano Niguarda Cà Granda, Milan.; Dipartimento Cardio-Toraco-Vascolare, Azienda Ligure della Sanità Regione Liguria.; Cardiology Division, Ospedale Garibaldi-Nesima, Azienda di Rilievo Nazionale e Alta Specializzazione 'Garibaldi', Catania.; Cardilogy Unit, Presidio Molinette, A.O.U. Città della Salute e della Scienza di Torino, Torino.; Cardiologia-UTIC-Emodinamica, Ospedale del Mare, Naples.; Cardiovascular Center, University Hospital and Health Services of Trieste, Trieste.; Fondazione per il Tuo cuore; Heart Care Foundation, Florence.; Division of Cardiology, Augusto Murri Hospital, Fermo, Ancona, Italy.

DOI: 10.2459/JCM.0000000000001108

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MeSH Terms: Biomarkers, Cholesterol, Dicarboxylic Acids, Fatty Acids, Humans, Hypercholesterolemia, Hypolipidemic Agents