Vaginal necrosis: A rare late toxicity after radiation therapy.

Angela Y Jia, Akila N Viswanathan

Journal: Gynecologic oncology 2021;160(2):602-609

PMID: 33303211

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Abstract

Vaginal necrosis is a late radiation tissue injury with serious morbidity complications. It is rare, and its incidence is not well assessed in prospective trials. Patient comorbidities and radiation dose can significantly increase the risk. As treatment of gynecologic malignancies often involve a multidisciplinary approach, timely diagnosis and appropriate management by physicians of the team are crucial. Untreated vaginal necrosis can lead to infection, hemorrhage, necrosis-related fistulation to the bladder or rectum, perforation, and death. In this review, we describe the pathophysiology of vaginal necrosis, its clinical course, and management options.

Address: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, United States of America.; Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, United States of America. Electronic address: [email protected].

DOI: 10.1016/j.ygyno.2020.11.025

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MeSH Terms: Anti-Bacterial Agents, Combined Modality Therapy, Debridement, Female, Genital Neoplasms, Female, Humans, Hydrogen Peroxide, Hyperbaric Oxygenation, Incidence, Necrosis, Radiation Injuries, Radiotherapy Dosage, Risk Factors, Treatment Outcome, Vagina, Vaginal Douching