Polyoxometalate-Based Nanomaterials Toward Efficient Cancer Diagnosis and Therapy.

Fei Lu, Mengzhen Wang, Na Li, Bo Tang

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 2021;27(21):6422-6434

PMID: 33314442

Abstract

As an emerging class of inorganic metal oxides, organically functionalized polyoxometalates (POMs) or POM-based nanohybrids have been demonstrated promising potential for the inhibition of various cancer types by the virtue of their diversity in structures and significantly reduced toxicity. This contribution summarizes the latest achievement of POM-based nanomaterials in cancer diagnosis and various therapeutics to put forward our fundamental viewpoints on the design principles of modified POMs based on their application. In addition, major challenges and perspectives in this field are also discussed. We expect that this review will provide a valuable and systematic reference for the further development of POM-based nanomaterials.

Address: College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical, Imaging in Universities of Shandong, Institute of Molecular and Nanoscience, Shandong Normal University, Jinan, 250014, P. R. China.

DOI: 10.1002/chem.202004500