Molybdenum-based hetero-nanocomposites for cancer therapy, diagnosis and biosensing application: Current advancement and future breakthroughs.

Namdev Dhas, Ritu Kudarha, Atul Garkal, Vivek Ghate, Shilpa Sharma, Prabhakar Panzade, Shubham Khot, Pinal Chaudhari, Ashutosh Singh, Mitali Paryani, Shaila Lewis, Neha Garg, Narinder Singh, Priyanka Bangar, Tejal Mehta

Journal: Journal of controlled release : official journal of the Controlled Release Society 2021;330():257-283

PMID: 33345832

Full Text on Elsevier Science View on PubMed

Abstract

In recent years, there have been significant advancements in the nanotechnology for cancer therapy. Even though molybdenum disulphide (MoS2)-based nanocomposites demonstrated extensive applications in biosensing, bioimaging, phototherapy, the review article focusing on MoS2 nanocomposite platform has not been accounted for yet. The review summarizes recent strategies on design and fabrication of MoS2-based nanocomposites and their modulated properties in cancer treatment. The review also discussed several therapeutic strategies (photothermal, photodynamic, immunotherapy, gene therapy and chemotherapy) and their combinations for efficient cancer therapy along with certain case studies. The review also inculcates various diagnostic techniques viz. magnetic resonance imaging, computed tomography, photoacoustic imaging and fluorescence imaging for diagnosis of cancer.

Address: Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat 382481, India.; Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat 390002, India.; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka 576104, India.; Department of Chemistry, Indian Institute of Technology, Ropar, Rupnagar, Punjab 140001, India.; Department of Pharmaceutics, Srinath College of Pharmacy, Dr. Babasaheb Ambedkar Technological University, Aurangabad, Maharashtra 431133, India.; Sinhgad Institute of Pharmacy, Narhe, Pune, Maharashtra 411041, India.; School of Basic Sciences, Indian Institute of Technology, Mandi, Kamand, Himachal Pradesh 175005, India.; Department of Medicinal Chemistry, Faculty of Ayurveda, Institute of Medical Sciences, BHU, Varanasi, Uttar Pradesh 221005, India.; Intas Pharmaceuticals Ltd., Ahmedabad, Gujarat 382213, India.; Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat 382481, India. Electronic address: [email protected].

DOI: 10.1016/j.jconrel.2020.12.015

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MeSH Terms: Disulfides, Humans, Immunotherapy, Molybdenum, Nanocomposites, Neoplasms, Phototherapy