Broadly effective metabolic and immune recovery with C5 inhibition in CHAPLE disease.

Address: Division of Allergy and Immunology, Department of Pediatrics, School of Medicine, Marmara University, Istanbul, Turkey. [email protected].; Istanbul Jeffrey Modell Diagnostic Center for Primary Immunodeficiency Diseases, Istanbul, Turkey. [email protected].; The Isil Berat Barlan Center for Translational Medicine, Istanbul, Turkey. [email protected].; Division of Allergy and Immunology, Department of Pediatrics, School of Medicine, Marmara University, Istanbul, Turkey.; Istanbul Jeffrey Modell Diagnostic Center for Primary Immunodeficiency Diseases, Istanbul, Turkey.; The Isil Berat Barlan Center for Translational Medicine, Istanbul, Turkey.; Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.; Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, NIH, Bethesda, MD, USA.; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, School of Medicine, Marmara University, Istanbul, Turkey.; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, School of Medicine, Gazi University, Ankara, Turkey.; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Baskent University Hospital, Ankara, Turkey.; Division of Allergy and Immunology, Department of Pediatrics, School of Medicine, Akdeniz University, Antalya, Turkey.; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Ataturk University, Erzurum, Turkey.; Division of Allergy and Immunology, Department of Pediatrics, Ministry of Health, Marmara University, Istanbul, Turkey.; Department of Pediatrics, School of Medicine, Marmara University, Istanbul, Turkey.; Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD, USA.; Clinical Genomics Program, NIAID, NIH, Bethesda, MD, USA.; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Kanuni Sultan Süleyman Training and Research Hospital, Health Sciences University, Istanbul, Turkey.; Division of Allergy and Immunology, Department of Pediatrics, School of Medicine, Inonu University, Malatya, Turkey.; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Alanya Alaaddin Keykubat University, Alanya, Turkey.; Department of Pathology, School of Medicine, Marmara University, Istanbul, Turkey.; Department of Pediatric Gastroenterology, University Medical Center-Wilhelmina Children's Hospital, Utrecht, the Netherlands.; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The American Genome Center, Henry Jackson Foundation, Uniformed Services University of Health Sciences, Bethesda, MD, USA.; Molecular Development of the Immune System Section and NIAID Clinical Genomics Program, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA.; Department of Anatomy, Physiology and Genetics, The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, USA.; Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA.; Department of Radiology, School of Medicine, Marmara University, Istanbul, Turkey.; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, School of Medicine, Akdeniz University, Antalya, Turkey.; Division of Pediatric Allergy and Immunology, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.; Clinical Genomics Program, NIAID, NIH, Bethesda, MD, USA. [email protected].; Molecular Development of the Immune System Section and NIAID Clinical Genomics Program, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA. [email protected].