Vascular dysfunction as a potential culprit of sarcopenia.

Yun Kyung Jeon, Myung Jun Shin, Sunil Kumar Saini, Carlo Custodero, Monica Aggarwal, Stephen D Anton, Christiaan Leeuwenburgh, Robert T Mankowski

Journal: Experimental gerontology 2021;145():111220

PMID: 33373710

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Abstract

Aging-related changes to biological structures such as cardiovascular and musculoskeletal systems contribute to the development of comorbid conditions including cardiovascular disease and frailty, and ultimately lead to premature death. Although, frail older adults often demonstrate both cardiovascular and musculoskeletal comorbidities, the etiology of sarcopenia, and especially the contribution of cardiovascular aging is unclear. Aging-related vascular calcification is prevalent in older adults and is a known risk factor for cardiovascular disease and death. The effect vascular calcification has on function during aging is not well understood. Emerging findings suggest vascular calcification can impact skeletal muscle perfusion, negatively affecting nutrient and oxygen delivery to skeletal muscle, ultimately accelerating muscle loss and functional decline. The present review summarizes existing evidence on the biological mechanisms linking vascular calcification with sarcopenia during aging.

Address: Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA; Division of Endocrinology and Metabolism, Department of Internal Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.; Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA; Department of Rehabilitation Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.; Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA.; Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA; Dipartimento Interdisciplinare di Medicina, Clinica Medica Cesare Frugoni, University of Bari Aldo Moro, Bari, Italy.; Department of Medicine, Division of Cardiovascular Medicine, University of Florida, FL, USA.; Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA. Electronic address: [email protected].

DOI: 10.1016/j.exger.2020.111220

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MeSH Terms: Aged, Aging, Frail Elderly, Frailty, Humans, Muscle, Skeletal, Sarcopenia