Iranian Salvia species: A phytochemical and pharmacological update.

Zahra Tayarani-Najaran, Sayyedeh Fatemeh Askari, Razieh Avan, Amirhossein Sahebkar, Samira Eghbali

Journal: Phytochemistry 2021;183():112619

PMID: 33373790

Full Text on Elsevier Science View on PubMed

Abstract

Salvia is the largest genus of the Lamiaceae family, with over 900 species in the world which about 60 species are distributed in Iran, 17 of them are endemic. In Iran, Salvia species have been used to treat various diseases with a wide spectrum of pharmacological activity in vitro and in vivo. The present review summarizes the phytochemistry and pharmacology of medicinal Iranian Salvia species in order to describe their therapeutic potential for a range of diseases. . Phytochemical investigations reveal that the Iranian Salvia has a varied range of metabolites including terpenoids, flavonoids and phenolic acids. The most important pharmacological activities are antidiabetic, antioxidant, antimicrobial, cytotoxic and anti-inflammatory. Iranian Salvia traditionally used as carminatives, analgesics, digestive aids, antiseptics, sedative, anxiolytic, hypnotic, pain reduction and antidiabetic. Among the endemic species, the most interesting for human health are treating a variety of diseases.

Address: Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran; Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.; Department of Clinical Pharmacy, Medical Toxicology and Drug Abuse Research Center (MTDRC), School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran.; Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Halal Research Center of IRI, FDA, Tehran, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Pharmacognosy, School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran; Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran. Electronic address: [email protected].

DOI: 10.1016/j.phytochem.2020.112619

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MeSH Terms: Antioxidants, Iran, Phytochemicals, Plant Extracts, Salvia