Effects of probiotic and alpha-lipoic acid supplements, separately or in combination on the anthropometric indicators and maintenance of weight in overweight individuals.

Gholamreza Nasiri, Ali Bastani, Ali Akbar Haji-Aghamohammadi, Mohamadreza Rashidi Nooshabadi, Parviz Shahmirzalou, Hossein Khadem Haghighian

Journal: Clinical nutrition ESPEN 2021;41():242-248

PMID: 33487271

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND & AIMS

Weight loss after proper diet is one of the main topics in nutrition. This study was designed to evaluate the effects of probiotic and alpha-Lipoic acid (ALA) supplements on the anthropometric indicators and maintenance of weight in overweight individuals.

METHODS

This study consisted of two phases of weight loss (8 weeks) and weight maintenance (16 weeks). Eighty-eight overweight participants were randomly divided into 4 groups in phase 1: isocaloric diet with probiotic (500 mg), an isocaloric diet with ALA (600 mg) and probiotic, an isocaloric diet with ALA and isocaloric diet with placebo. In phase 2, participants received a normal diet with the mentioned supplements. In the beginning, end of the phase 1, and at the end of phase 2, weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), body fat percentage, and blood pressure (BP) were measured. Also, 10 cc blood samples were taken from subjects to measure C-reactive protein (CRP). Data was analyzed using SPSS software.

RESULTS

At the end of the two phases, the differences of changes in the probiotic + ALA group was significant in weight, WC, and CRP factors when compared to the other groups (P < 0.05). Also, at the end of the study, maintain a reduced weight was significantly higher in the probiotic + ALA group than in the other groups (P < 0.05).

CONCLUSION

According to findings, probiotics and ALA supplementation with normal diet help to maintain decreased weight after adhering to a weight loss diet. This may be due to the reduction of inflammation.

TRIAL REGISTRATION

(IRCT20141025019669N10).

Address: Student Research Committee, School of Health, Qazvin University of Medical Sciences, Qazvin, Iran.; Department of Internal Medicine, Velayat Clinical Research Development Unit, Qazvin University of Medical Sciences, Qazvin, Iran.; Department of Pharmacology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Department of Biostatistics, Khoy University of Medical Sciences, Khoy, Iran.; Student Research Committee, School of Health, Qazvin University of Medical Sciences, Qazvin, Iran; Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran. Electronic address: [email protected].

DOI: 10.1016/j.clnesp.2020.12.007