Regulation of pro-σ activation: a key checkpoint in Bacillus subtilis sporulation.

Gaohui Sun, Moua Yang, Longguang Jiang, Mingdong Huang

Journal: Environmental microbiology 2021;23(5):2366-2373

PMID: 33538382

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Abstract

The Gram-positive bacterium Bacillus subtilis initiates the sporulation process under conditions of nutrient limitation. Here, we review related work in this field, focusing on the protein processing of the pro-σ activation. The purpose of this review is to illustrate the mechanism of pro-σ activation and provide structural insights into the regulation of spore production. Sporulation is not only important in basic science but also provides mechanistic insight for bacterial control in applications in, e.g., food industry.

Address: College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350016, China.; Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.; Fujian Key Laboratory of Marine Enzyme Engineering, Fuzhou University, Fuzhou, Fujian, 350116, China.

DOI: 10.1111/1462-2920.15415

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MeSH Terms: Bacillus subtilis, Bacterial Proteins, Gene Expression Regulation, Bacterial, Sigma Factor, Spores, Bacterial