Bioresorbable Metals for Biomedical Applications: From Mechanical Components to Electronic Devices.

Hanjun Ryu, Min-Ho Seo, John A Rogers

Journal: Advanced healthcare materials 2021;10(17):e2002236

PMID: 33586341

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Abstract

Bioresorbable metals and metal alloys are of growing interest for myriad uses in temporary biomedical implants. Examples range from structural elements as stents, screws, and scaffolds to electronic components as sensors, electrical stimulators, and programmable fluidics. The associated physical forms span mechanically machined bulk parts to lithographically patterned conductive traces, across a diversity of metals and alloys based on magnesium, zinc, iron, tungsten, and others. The result is a rich set of opportunities in healthcare materials science and engineering. This review article summarizes recent advances in this area, starting with an historical perspective followed by a discussion of materials options, considerations in biocompatibility, and device applications. Highlights are in system level bioresorbable electronic platforms that support functions as diagnostics and therapeutics in the context of specific, temporary clinical needs. A concluding section highlights challenges and emerging research directions.

Address: Center for Bio-Integrated Electronics, Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, 60208, USA.; School of Biomedical Convergence Engineering, College of Information & Biomedical Engineering, Pusan National University 49, Busandaehak-ro, Yangsan-si, Gyeongsangnam-do, 50612, Republic of Korea.; Department of Mechanical Engineering, Northwestern University, Evanston, IL, 60208, USA.; Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL, 60208, USA.; Department of Materials Science and Engineering, Northwestern University, Evanston, IL, 60208, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.; Department of Chemistry, Northwestern University, Evanston, IL, 60208, USA.; Department of Electrical and Computer Engineering, Northwestern University, Evanston, IL, 60208, USA.; Departments of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.

DOI: 10.1002/adhm.202002236

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MeSH Terms: Absorbable Implants, Alloys, Electronics, Magnesium, Stents