beta-Endorphin modulation of pressor response to hyperventilation in hypertensive patients.

Fiorella Fontana, Pasquale Bernardi, Santi Spampinato, Rosanna Di Toro, Raffaele Bugiardini

Journal: Peptides 2003;23(5):911-8

PMID: 12084522

Full Text on Elsevier Science View on PubMed

Abstract

After hyperventilation, systolic and diastolic blood pressure (BP) significantly decreased in 14 hypertensive patients (group 1), did not change in 9 (group 2) and increased in 8 (group 3). Basal BP, norepinephrine and dynorphin B levels were higher in group 1 than in groups 2 and 3. The decrease in BP after hyperventilation was associated with a decrease in plasma norepinephrine, Met-enkephalin and dynorphin B and an increase in beta-endorphin. Naloxone abolished the hyperventilation-induced BP and norepinephrine decreases. Our findings indicate that hyperventilation may select hypertensive patients with different sympatho-adrenergic activity and that the increase in beta-endorphin reduces BP response to hyperventilation in patients with high sympatho-adrenergic tone.

Address: Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, Ospedale S. Orsola, Via Massarenti 9, Bologna, Italy. [email protected]

DOI: 10.1016/s0196-9781(02)00018-9

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MeSH Terms: Aged, Blood Pressure, Cross-Over Studies, Dynorphins, Enkephalin, Methionine, Female, Heart Rate, Humans, Hypertension, Hyperventilation, Male, Middle Aged, Naloxone, Norepinephrine, Time Factors, beta-Endorphin