Effect of Surgically Induced Weight Loss on Biomarkers of Endothelial Dysfunction: a Systematic Review and Meta-Analysis.

Javad Seyyedi, Shahab Alizadeh

Journal: Obesity surgery 2021;30(9):3549-3560

PMID: 32483744

Abstract

BACKGROUND

This meta-analysis was performed to assess the effects of bariatric surgery (BS) on the selected markers of endothelial dysfunction, including monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin.

METHODS

PubMed, Scopus, and Google scholar were systematically searched to identify related studies published from inception to November 2019 to find eligible studies.

RESULTS

A total of 29 different studies were included. BS reduced the concentrations of MCP-1 (weighted mean difference (WMD) = - 58.91; 95%CI (confidence interval), - 77.10 to - 40.72; P = ˂ 0.001), ICAM-1 (WMD = - 36.58; 95%CI, - 49.65 to - 23.52; P = ˂ 0.001), and E-selectin (WMD = - 11.22; 95%CI, - 14.43 to - 8.01; P < 0.001), but had no significant effect on VCAM-1.

CONCLUSION

Bariatric surgery reduces circulating concentration of MCP-1, ICAM-1, and E-selectin, but not VCAM-1.

Address: Department of Medical Surgical Nursing, School of Nursing & Midwifery, Tehran University of Medical Sciences, Tehran, Iran.; Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. [email protected].

DOI: 10.1007/s11695-020-04710-1

Link outs

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https://medlineplus.gov/weightcontrol.html

Miscellaneous:

https://assays.cancer.gov/non-CPTAC-3397

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-OTUB1-1

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Full Text Sources:

https://dx.doi.org/10.1007/s11695-020-04710-1

MeSH Terms: Biomarkers, E-Selectin, Endothelium, Vascular, Humans, Intercellular Adhesion Molecule-1, Obesity, Morbid, Vascular Cell Adhesion Molecule-1, Weight Loss