Platelets immune response against Mycobacterium tuberculosis infection.

Flor Torres-Juarez, Luis A Trejo-Martínez, Esther Layseca-Espinosa, Juan C Leon-Contreras, Jose A Enciso-Moreno, Rogelio Hernandez-Pando, Bruno Rivas-Santiago

Journal: Microbial pathogenesis 2021;153():104768

PMID: 33524564

Full Text on Elsevier Science View on PubMed

Abstract

Tuberculosis (TB) is the first cause of death by a single infectious agent. Previous reports have highlighted the presence of platelets within Tb granulomas, albeit the immune-associated platelet response to Mycobacterium tuberculosis (Mtb) has not been deeply studied. Our results showed that platelets are recruited into the granuloma in the late stages of tuberculosis. Furthermore, electron-microscopy studies showed that platelets can internalize Mtb and produce host defense peptides (HDPs), such as RNase 7, HBD2 and hPF-4 that bind to the internalized Mtb. Mtb-infected platelets exhibited higher transcription and secretion of IL-1β and TNF-α, whereas IL-10 and IL-6 protein levels decreased. These results suggest that platelets participate in the immune response against Mtb through HDPs and cytokines production.

Address: Biomedical Research Unit of Zacatecas-Mexican Institute of Social Security, Zacatecas, Mexico; Laboratory of Immunology, Autonomous University of San Luis Potosí, San Luis Potosi, Mexico.; Biomedical Research Unit of Zacatecas-Mexican Institute of Social Security, Zacatecas, Mexico.; Laboratory of Immunology, Autonomous University of San Luis Potosí, San Luis Potosi, Mexico.; Laboratory of Experimental Pathology, Nacional Institute of Medical Sciences and Nutrition "Salvador Zubiran", CDMX, Mexico.; Biomedical Research Unit of Zacatecas-Mexican Institute of Social Security, Zacatecas, Mexico. Electronic address: [email protected].

DOI: 10.1016/j.micpath.2021.104768

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MeSH Terms: Blood Platelets, Cytokines, Granuloma, Humans, Immunity, Mycobacterium tuberculosis, Tuberculosis