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The Role of GSH in Intracellular Iron Trafficking.

Robert Hider, Mayra Vera Aviles, Yu-Lin Chen, Gladys Oluyemisi Latunde-Dada

Journal: International journal of molecular sciences 2021;22(3):1278

PMID: 33525417

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Abstract

Evidence is reviewed for the role of glutathione in providing a ligand for the cytosolic iron pool. The possibility of histidine and carnosine forming ternary complexes with iron(II)glutathione is discussed and the physiological significance of these interactions considered. The role of carnosine in muscle, brain, and kidney physiology is far from established and evidence is presented that the iron(II)-binding capability of carnosine relates to this role.

Address: Institute of Pharmaceutical Science, King's College London, London SE1 9NH, UK.
DOI: 10.3390/ijms22031278

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MeSH Terms: Brain, Carnosine, DNA-Binding Proteins, Gene Expression Regulation, Glutathione, Histidine, Humans, Hydrogen-Ion Concentration, Hypoxia-Inducible Factor 1, alpha Subunit, Iron, Iron Chelating Agents, Iron Regulatory Protein 1, Iron Regulatory Protein 2, Kidney, Mitochondria, Muscles, RNA-Binding Proteins
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