Natural bioeffective cyclooligopeptides from plant seeds of Annona genus.

Rajiv Dahiya, Sunita Dahiya

Journal: European journal of medicinal chemistry 2021;214():113221

PMID: 33540356

Full Text on Elsevier Science View on PubMed

Abstract

The Annona L. is one of the most significant genus of the Annonaceae family due to its widespread medicinal properties. This genus has a variety of active metabolites, including alkaloids, isoquinolines, peptides, acetogenins, lectins, volatile oils etc. Due to the constitution of cyclopeptides with an expanded spectrum of distinctive bioproperties, this genus is predominantly preferred over other species. The cytotoxicity, vasorelaxant activity, anti-inflammatory and other properties exhibited by cyclooligopeptides from seeds of Annona genus plants make these metabolites attractive leads for the drug discovery process. The present review covers the structural characteristics, structure activity relationship, synthesis strategies, pharmacological properties of plant seeds-originated bioactive peptides from Annona genus, which may be vital for the development of novel therapeutics based on peptide skeleton.

Address: School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago, West Indies. Electronic address: [email protected].; Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico, Medical Sciences Campus, San Juan, PR, 00936, USA. Electronic address: [email protected].

DOI: 10.1016/j.ejmech.2021.113221

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MeSH Terms: Annona, Anti-Inflammatory Agents, Antineoplastic Agents, Phytogenic, Biological Products, Humans, Molecular Structure, Oligopeptides, Plant Extracts, Seeds