Elevated gut microbiome abundance of is associated with reduced visceral adipose tissue and healthier metabolic profile in Italian elderly.

Teresa Tavella, Simone Rampelli, Giulia Guidarelli, Alberto Bazzocchi, Chiara Gasperini, Estelle Pujos-Guillot, Blandine Comte, Monica Barone, Elena Biagi, Marco Candela, Claudio Nicoletti, Fawzi Kadi, Giuseppe Battista, Stefano Salvioli, Paul W O'Toole, Claudio Franceschi, Patrizia Brigidi, Silvia Turroni, Aurelia Santoro

Journal: Gut microbes 2022;13(1):1-19

PMID: 33557667

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Abstract

Aging is accompanied by physiological changes affecting body composition and functionality, including accumulation of fat mass at the expense of muscle mass, with effects upon morbidity and quality of life. The gut microbiome has recently emerged as a key environmental modifier of human health that can modulate healthy aging and possibly longevity. However, its associations with adiposity in old age are still poorly understood. Here we profiled the gut microbiota in a well-characterized cohort of 201 Italian elderly subjects from the NU-AGE study, by 16S rRNA amplicon sequencing. We then tested for association with body composition from dual-energy X-ray absorptiometry (DXA), with a focus on visceral and subcutaneous adipose tissue. Dietary patterns, serum metabolome and other health-related parameters were also assessed. This study identified distinct compositional structures of the elderly gut microbiota associated with DXA parameters, diet, metabolic profiles and cardio-metabolic risk factors.

Address: Unit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bologna , Bologna, Italy.; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna , Bologna, Italy.; Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Rizzoli , Bologna, Italy.; Université Clermont Auvergne, INRAE, UNH, Plateforme d'Exploration Du Métabolisme, MetaboHUB Clermont , Clermont- Ferrand, France.; Gut Health Institute Strategic Programme, Quadram Institute Bioscience , Norwich, UK.; Department of Experimental and Clinical Medicine, Section of Anatomy, University of Florence , Florence, Italy.; School of Health Sciences, Örebro University , Örebro, Sweden.; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna , Bologna, Italy.; Alma Mater Research Institute on Global Challenges and Climate Change (Alma Climate), University of Bologna , Bologna, Italy.; School of Microbiology, University College Cork , Cork, Ireland.; APC Microbiome Ireland, University College Cork , Cork, Ireland.; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna , Bologna, Italy.; Department of Applied Mathematics, Institute of Information Technology, Mathematics and Mechanics (ITMM), Lobachevsky State University of Nizhny Novgorod-National Research University (UNN) , Nizhny Novgorod, Russia.; Department of Medical and Surgical Sciences, University of Bologna , Bologna, Italy.

DOI: 10.1080/19490976.2021.1880221

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https://medlineplus.gov/olderadulthealth.html

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https://scite.ai/reports/33557667

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https://antibodies.cancer.gov/detail/CPTC-PSMA1-1

MeSH Terms: Aged, Aging, Bacteroidetes, Body Composition, Clostridiales, Diet, Female, Gastrointestinal Microbiome, Humans, Intra-Abdominal Fat, Italy, Male, Metabolome, Subcutaneous Fat, Abdominal