Furanodiene: A Novel, Potent, and Multitarget Cancer-fighting Terpenoid.

Rabia Batool, Azhar Rasul, Ghulam Hussain, Muhammad Ajmal Shah, Bushra Nageen, Iqra Sarfraz, Muhammad Kashif Zahoor, Ammara Riaz, Aiza Ajaz, Şevki Adem

Journal: Current pharmaceutical design 2021;27(22):2628-2634

PMID: 33573548

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Abstract

Natural products have served as a limitless reservoir of bioactive scaffolds for drug discovery against several disorders. Furanodiene is a bioactive natural product isolated from several plants of genus Curcuma. Its therapeutic potential against cancer, inflammation, and angiogenesis has been well-documented. The current review is an update about the natural sources and anti-cancer action mechanism of furanodiene. Furanodiene exerts its anti-cancer effects via induction of apoptosis in several cancer types by modulating MAPKs/ERK, NF-κB, and Akt pathways. Furanodiene has been systematically studied for its anti-cancer potential. However, pharmacokinetics, pharmacodynamics, pre-clinical and clinical studies still needed to be conducted to completely validate the potential of furanodiene for the treatment of cancer.

Address: Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000, Pakistan.; Neurochemicalbiology and Genetics Laboratory (NGL), Department of Physiology, Faculty of Life Sciences, Government College University Faisalabad, 38000, Pakistan.; Department of Pharmacognosy, Faculty of Life Sciences, Government College University Faisalabad, 38000, Pakistan.; Department of Chemistry, Faculty of Science, Cankiri Karatekin University, 18100 Cankiri, Turkey.

DOI: 10.2174/1381612827666210211125304