Study of fucoidans as natural biomolecules for therapeutical applications in osteoarthritis.

Carlos Vaamonde-García, Noelia Flórez-Fernández, María Dolores Torres, María J Lamas-Vázquez, Francisco J Blanco, Herminia Domínguez, Rosa Meijide-Faílde

Journal: Carbohydrate polymers 2021;258():117692

PMID: 33593565

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Abstract

Osteoarthritis (OA) is the most prevalent articular chronic disease. Although, to date there is no cure for OA. Fucoidans, one of the main therapeutic components of brown algae, have emerged as promising molecules in OA treatment. However, the variability between fucoidans makes difficult the pursuit of the most suitable candidate to target specific pathological processes. By an in vitro experimental approach in chondrocytes and fibroblast-like synoviocytes, we observed that chemical composition of fucoidan, and specifically the phlorotannin content and the ratio sulfate:fucose, seems critically relevant for its biological activity. Nonetheless, other factors like concentration and molecular weight of the fucoidan may influence on its beneficial effects. Additionally, a cell-type dependent response was also detected. Thus, our results shed light on the potential use of fucoidans as natural molecules in the treatment of key pathological processes in the joint that favor the development of rheumatic disorders as OA.

Address: Tissue Engineering and Cellular Therapy Group, Department of Physiotherapy, Medicine and Biological Sciences, University of A Coruña, A Coruña, Spain; Unidad de Medicina Regenerativa, Grupo de Investigación de Reumatología (GIR), Instituto de InvestigaciónBiomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade da Coruña (UDC), C/ As Xubias de Arriba 84, 15006, A Coruña, España; Centro de Investigaciones Científicas Avanzadas (CICA), As Carballeiras S/N, Campus de Elviña, 15071, A Coruña, España. Electronic address: [email protected].; Department of Chemical Engineering, University of Vigo, Faculty of Sciences, Ourense, Spain; CINBIO, Universidade de Vigo, Departamento de Ingeniería Química, Campus Ourense, 32004 Ourense, Spain. Electronic address: [email protected].; Department of Chemical Engineering, University of Vigo, Faculty of Sciences, Ourense, Spain; CINBIO, Universidade de Vigo, Departamento de Ingeniería Química, Campus Ourense, 32004 Ourense, Spain. Electronic address: [email protected].; Tissue Engineering and Cellular Therapy Group, Department of Physiotherapy, Medicine and Biological Sciences, University of A Coruña, A Coruña, Spain. Electronic address: [email protected].; Unidad de Medicina Regenerativa, Grupo de Investigación de Reumatología (GIR), Instituto de InvestigaciónBiomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade da Coruña (UDC), C/ As Xubias de Arriba 84, 15006, A Coruña, España; Centro de Investigaciones Científicas Avanzadas (CICA), As Carballeiras S/N, Campus de Elviña, 15071, A Coruña, España. Electronic address: [email protected].; Department of Chemical Engineering, University of Vigo, Faculty of Sciences, Ourense, Spain; CINBIO, Universidade de Vigo, Departamento de Ingeniería Química, Campus Ourense, 32004 Ourense, Spain. Electronic address: [email protected].; Tissue Engineering and Cellular Therapy Group, Department of Physiotherapy, Medicine and Biological Sciences, University of A Coruña, A Coruña, Spain; Centro de Investigaciones Científicas Avanzadas (CICA), As Carballeiras S/N, Campus de Elviña, 15071, A Coruña, España. Electronic address: [email protected].

DOI: 10.1016/j.carbpol.2021.117692

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Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0144...

Medical:

https://medlineplus.gov/osteoarthritis.html

Other Literature Sources:

https://scite.ai/reports/33593565

MeSH Terms: Aged, Aged, 80 and over, Antioxidants, Apoptosis, Cartilage, Articular, Chondrocytes, Female, Fibroblasts, Fucose, Fucus, Humans, In Vitro Techniques, Macrocystis, Male, Membrane Potential, Mitochondrial, Middle Aged, Oligosaccharides, Osteoarthritis, Phloroglucinol, Polysaccharides, Reactive Oxygen Species, Rheumatic Diseases, Sulfates, Synoviocytes, Undaria