The Immune Response and Effectiveness of COVID-19 Therapies.

Fataneh Tavasolian, Gholam Reza Hatam, Sayed Hussain Mosawi, Mahdiyar Iravani Saadi, Elham Abdollahi, Tannaz Jamialahmadi, Thozhukat Sathyapalan, Amirhossein Sahebkar

Journal: Advances in experimental medicine and biology 2021;1321():115-126

PMID: 33656718

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Abstract

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly pathogenic with relatively high mortality and morbidity. In addition to pneumonia, acute respiratory distress syndrome, and microembolic disorder, a high proportion of patients with SARS-CoV-2 develop lymphopenia and cytokine storm disorder. This review explores the underlying mechanisms behind the pathogenesis of SARS-CoV-2, especially the immune mechanisms, which could be potentially used as therapeutic targets for the management of COVID-19.

Address: Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.; Basic Sciences in Infectious Diseases Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.; Medical Sciences Research Center, Ghalib University, Kabul, Afghanistan.; Hematology Research Center, Department of Hematology, Medical Oncology and Stem Cell Transplantation, Shiraz University of Medical Sciences, Shiraz, Iran.; Department of Medical Immunology and Allergy, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Iran.; Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. [email protected].; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. [email protected].; Halal Research Center of IRI, FDA, Tehran, Iran. [email protected].; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland. [email protected].

DOI: 10.1007/978-3-030-59261-5_10