Pleiotropic Effects of Eugenol: The Good, the Bad, and the Unknown.

Oana M Aburel, Ioana Z Pavel, Maria D Dănilă, Theia Lelcu, Alexandra Roi, Rodica Lighezan, Danina M Muntean, Laura C Rusu

Journal: Oxidative medicine and cellular longevity 2021;2021():3165159

PMID: 33747344

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Abstract

Phytocompounds and medicinal herbs were used in traditional ancient medicine and are nowadays increasingly screened in both experimental and clinical settings due to their beneficial effects in several major pathologies. Similar to the drug industry, phytotherapy is interested in using nanobased delivery systems to view the identification and characterization of the cellular and molecular therapeutic targets of plant components. Eugenol, the major phenolic constituent of clove essential oil, is a particularly versatile phytochemical with a vast range of therapeutic properties, among which the anti-inflammatory, antioxidant, and anticarcinogenic effects have been systematically addressed. In the past decade, with the emerging understanding of the role of mitochondria as critical organelles in the pathophysiology of noncommunicable diseases, research regarding the role of phytochemicals as modulators of bioenergetics and metabolism is on a rise. Here, we present a brief overview of the major pharmacological properties of eugenol, with special emphasis on its applications in dental medicine, and provide preliminary data regarding its effects, alone, and included in polyurethane nanostructures, on mitochondrial bioenergetics, and glycolysis in human HaCaT keratinocytes.

Address: Department of Functional Sciences-Pathophysiology, Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timișoara, Romania.; Center for Translational Research and Systems Medicine, Faculty of Medicine, "Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timișoara, Romania.; Department II-Pharmacognosy, Faculty of Pharmacy, "Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timișoara, Romania.; Pharmaco-Toxicological Evaluations Research Center, Faculty of Pharmacy, "Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timișoara, Romania.; Department-Oral Pathology, Faculty of Dentistry, "Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timișoara, Romania.; Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, Faculty of Dentistry, "Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timișoara, Romania.; Department of Infectious Diseases-Parasitology, Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timișoara, Romania.; Center for Diagnostic and Study of Parasitic Diseases, Faculty of Medicine, "Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timișoara, Romania.

DOI: 10.1155/2021/3165159

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https://assays.cancer.gov/CPTAC-68

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https://antibodies.cancer.gov/detail/CPTC-BAD-1

MeSH Terms: Anti-Inflammatory Agents, Antioxidants, Dentistry, Eugenol, Humans, Mitochondria, Protective Agents