Proteins Interacting with STIM1 and Store-Operated Ca Entry.

Wen-An Wang, Nicolas Demaurex

Journal: Progress in molecular and subcellular biology 2021;59():51-97

PMID: 34050862

Abstract

The endoplasmic reticulum (ER) Ca sensor stromal interaction molecule 1 (STIM1) interacts with ORAI Ca channels at the plasma membrane to regulate immune and muscle cell function. The conformational changes underlying STIM1 activation, translocation, and ORAI1 trapping and gating, are stringently regulated by post-translational modifications and accessory proteins. Here, we review the recent progress in the identification and characterization of ER and cytosolic proteins interacting with STIM1 to control its activation and deactivation during store-operated Ca entry (SOCE).

Address: Department of Cellular Physiology and Metabolism, University of Geneva, Geneva, Switzerland.; Department of Cellular Physiology and Metabolism, University of Geneva, Geneva, Switzerland. [email protected].

DOI: 10.1007/978-3-030-67696-4_4

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https://dx.doi.org/10.1007/978-3-030-67696-4_4

MeSH Terms: Calcium, Calcium Channels, Calcium Signaling, Membrane Proteins, ORAI1 Protein, Stromal Interaction Molecule 1