Recent Opportunities and Challenges in Selective C-H Functionalization of Methyl Azaarenes: A Highlight from 2010 to 2020 Studies.

Fahimeh Abedinifar, Mohammad Mahdavi, Mehdi Asadi, Haleh Hamedifar, Samira Ansari, Bagher Larijani

Journal: Current organic synthesis 2022;18(8):761-789

PMID: 34126907

Abstract

Azaarenes are unique scaffolds that are frequently found in pharmaceuticals. Herein we have summarized the recent synthetic available methods in C-H functionalization of methylazaarenes from 2010 to 2020. Multiple approaches involving halogenation, alkylation via different methods, alkenylation, oxidative functionalization, and cyclization of the methylazaarenes will be discussed in this review.

Address: Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran 14176, Iran.; CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran.

DOI: 10.2174/1566524021666210614141628

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MeSH Terms: Alkylation, Catalysis, Cyclization, Halogenation