Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk.

Alina Solomon, Ron Handels, Anders Wimo, Riitta Antikainen, Tiina Laatikainen, Esko Levälahti, Markku Peltonen, Hilkka Soininen, Timo Strandberg, Jaakko Tuomilehto, Miia Kivipelto, Tiia Ngandu

Journal: Journal of Alzheimer's disease : JAD 2021;82(4):1461-1466

PMID: 34151805

Free Full Text on Atypon View on PubMed

Plain Language Summary

Early identification of individuals at-risk of dementia is essential for effective preventive strategies. The aim of this study was to investigate the effect of a multidomain lifestyle intervention on the risk of dementia. This study is a post-hoc analyses of intervention effects on change in the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) Dementia Risk Score. The CAIDE score was used to select at-risk participants to the FINGER trial. FINGER is a multicentre study conducted in 6 centres in Finland. Results show a significant beneficial intervention effect, especially in women, on reducing estimated dementia risk measured by the CAIDE score. Authors conclude that CAIDE risk score can be used as a tool to communicate dementia risk, and to select persons that may benefit from lifestyle interventions.

Abstract

We investigated the effect of a multidomain lifestyle intervention on the risk of dementia estimated using the validated CAIDE risk score (post-hoc analysis). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a 2-year randomized controlled trial among 1,260 at-risk older adults (60-77 years). Difference in the estimated mean change in CAIDE score at 2 years in the intervention compared to the control group was -0.16 (95 %CI -0.31 to 0.00) (p = 0.013), corresponding to a relative dementia risk reduction between 6.04-6.50%. This could be interpreted as a reflection of the prevention potential of the intervention.

Address: Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.; Karolinska Institutet, NVS, Division of Clinical Geriatrics, Solna, Stockholm, Sweden.; Alzheimer Centre Limburg, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.; Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands.; Karolinska Institutet, NVS, Division of Neurogeriatrics, Stockholm, Sweden.; Karolinska Institutet, NVS, Division of Neurogeriatrics, Stockholm, Sweden.; Center for Life Course Health Research, University of Oulu, Oulu, Finland.; Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland.; Oulu City Hospital, Oulu, Finland.; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.; Hospital District of North Karelia, Joensuu, Finland.; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.; Neurocenter, Department of Neurology, Kuopio University Hospital, Kuopio, Finland.; Center for Life Course Health Research, University of Oulu, Oulu, Finland.; University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; National School of Public Health, Madrid, Spain.; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.; Karolinska Institutet, NVS, Division of Clinical Geriatrics, Solna, Stockholm, Sweden.; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.; Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, United Kingdom.; Karolinska Institutet, NVS, Division of Clinical Geriatrics, Solna, Stockholm, Sweden.; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.

DOI: 10.3233/JAD-210331

Patient Centred Factor

Mediators: Dementia

Physical Environment

Psychosocial influences

Clinical Imbalances

Neurological

Nutrition Evidence Keywords

Physical activity Cholesterol Body mass index Blood pressure

Link outs

Free resources

Full Text Sources:

Medical:

Subscription / membership required

Full Text Sources:

https://content.iospress.com/openurl?genre=article...

MeSH Terms: Aged, Cognitive Dysfunction, Dementia, Exercise, Female, Finland, Humans, Life Style, Male, Nutrition Assessment, Risk Factors, Risk Reduction Behavior