Structure and Functions of Bacterial Outer Membrane Protein A, A Potential Therapeutic Target for Bacterial Infection.

Qingfeng Guan, Biswajit Bhowmick, Archana Upadhyay, Qian Han

Journal: Current topics in medicinal chemistry 2021;21(13):1129-1138

PMID: 34225622

Abstract

Outer membrane protein A (OmpA) is a unique outer membrane protein which is abundantly present in the outer membrane of Gram-negative bacteria. OmpA is a transmembrane structural protein with a conserved amino acid sequence among different bacteria. This protein is involved in a number of functions like adhesion, toxicity, invasiveness, and biofilm formation in Gram-negative bacteria. Many studies have proposed that OmpA could be a therapeutic target for bacterial infection. Our review focusses on the studies involving recent development in the structure and functions of OmpA and further discussing its potential as a therapeutic target for bacterial infection.

Address: Laboratory of Tropical Veterinary Medicine and Vector Biology, School of Life Sciences, Hainan University, Haikou, Hainan 570228, China.

DOI: 10.2174/1568026621666210705164319

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MeSH Terms: Anti-Bacterial Agents, Bacterial Infections, Bacterial Outer Membrane Proteins, Models, Molecular