Characteristics and patterns of pediatric chemotherapy-induced peripheral neuropathy: A systematic review.

Ellen M Lavoie Smith, Clare Kuisell, Youmin Cho, Grace A Kanzawa-Lee, Laura S Gilchrist, Susanna B Park, Mary R Scott, Paola Alberti

Journal: Cancer treatment and research communications 2022;28():100420

PMID: 34225104

Free Full Text on Elsevier Science View on PubMed

Abstract

This systematic review provides a high-quality synthesis of the empirical evidence regarding chemotherapy-induced peripheral neuropathy (CIPN) characteristics and patterns described in studies of children who received neurotoxic chemotherapy to treat cancer. PubMed, CINAHL, PsycINFO, and Embase were searched for articles published 2009 - 2019, yielding 861. Forty-two papers met the eligibility criteria, including 31 that described characteristics and patterns of vincristine-induced CIPN. Fifty-seven percent of articles were of low to moderate quality; measurement flaws were the most common limitations. The reported CIPN incidence varies widely (2.8%-100%) depending on risk factors (e.g., race) and the measurement approach. Incidence rates of sensory, motor, autonomic CIPN, and pain were 12-28%, 50-72%, 0.8-83% and 5.7-44%, respectively. The evidence suggests that sensory and motor neuropathy, pain, and functional deficits are common and can persist into adulthood. Caucasian race is a risk factor and, contrary to prior thinking, cumulative chemotherapy dosage alone does not predict CIPN severity. The influence of other risk factors is less clear, and studies to date have not explored potential interactions among race, genetics, age, sex, drug metabolism, and nutritional status, among other factors.

Address: University of Alabama at Birmingham School of Nursing, Birmingham, AL 35294 USA. Electronic address: [email protected].; University of Michigan School of Nursing, Ann Arbor, MI, 48109 USA. Electronic address: [email protected].; University of Michigan School of Nursing, Ann Arbor, MI, 48109 USA. Electronic address: [email protected].; University of Michigan School of Nursing, Ann Arbor, MI, 48109 USA. Electronic address: [email protected].; St. Catherine University, Doctor of Physical Therapy Program, St. Paul, MN, 55105. Electronic address: [email protected].; University of Sydney, Brain and Mind Centre, Faculty of Medicine and Health, Camperdown NSW 2050, Australia. Electronic address: [email protected].; University of Alabama at Birmingham School of Nursing, Birmingham, AL 35294 USA. Electronic address: [email protected].; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza (MB), Italy; NeuroMI (Milan Center for Neuroscience), Milan, Italy. Electronic address: [email protected].

DOI: 10.1016/j.ctarc.2021.100420