Genus : Therapeutic Potentialities and Agro-Food-Pharma Applications.

Javad Sharifi-Rad, Cristina Quispe, Cristian Valdés Vergara, Dusanka Kitic, Milica Kostic, Lorene Armstrong, Zabta Khan Shinwari, Ali Talha Khalil, Milka Brdar-Jokanović, Branka Ljevnaić-Mašić, Elena M Varoni, Marcello Iriti, Gerardo Leyva-Gómez, Jesús Herrera-Bravo, Luis A Salazar, William C Cho

Journal: Oxidative medicine and cellular longevity 2022;2021():3095514

PMID: 34326915

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Abstract

The genus (Adoxaceae, Dipsacales) is of scientific interest due to the chemical components and diverse biological activities found across species of the genus, which includes more than 230 species of evergreen, semievergreen, or deciduous shrubs and small trees. Although frequently used as an ornament, the species show biological properties with health-promoting effects. Fruits, flowers, and barks of certain species are used for pharmaceutical purposes or as cooking ingredients, hence containing biochemical compounds with health-promoting activity such are carotenoids, polyphenols, and flavonoids. However, its taxonomical determination is difficult, due to its wide distribution and frequent hybridizations; therefore, an objective classification would allow us to understand its biological activity based on its phytochemical components. More than sixty phytochemical compounds have been reported, where vibsanin-type diterpenes and their derivatives are the most prevalent. Leaves and twigs of contain the largest number of phytochemicals among the genus. Through preclinical evidence, this study provides insight regarding antioxidant, antibacterial, anti-inflammatory, cytotoxic, and anticancer activities of genus .

Address: Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique 1110939, Chile.; Centro de Investigación de Estudios Avanzados del Maule, Vicerrectoría de Investigación y Postgrado, Universidad Católica del Maule, Chile.; Faculty of Medicine, Department of Pharmacy, University of Niš, Ave. Zorana Djindjica 81, 18000 Nis, Serbia.; Departament of Pharmaceutical Sciences, State University of Ponta Grossa, 84030900, Ponta Grossa, Paraná, Brazil.; Department of Plant Sciences, Quaid-i-Azam University, Islamabad, Pakistan.; Pakistan Academy of Sciences, Islamabad, Pakistan.; Department of Pathology, Lady Reading Hospital Medical Teaching Institution, Peshawar (25000), KP, Pakistan.; Institute of Field and Vegetable Crops, National Institute of the Republic of Serbia, Alternative Crops and Organic Production Department, Maksima Gorkog 30, 21000 Novi Sad, Serbia.; Faculty of Agriculture, Department of Field and Vegetable Crops, University of Novi Sad, Trg Dositeja Obradovića 8, 21000 Novi Sad, Serbia.; Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università Degli Studi di Milano, Via Beldiletto 1, 20142 Milan, Italy.; Dipartimento di Scienze Agrarie e Ambientali, Via Celoria 2, 20133 Milan, Italy.; Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México 04510, Mexico.; Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomas, Chile.; Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de La Frontera, Temuco 4811230, Chile.; Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de La Frontera, Temuco 4811230, Chile.; Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong.

DOI: 10.1155/2021/3095514

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MeSH Terms: Antineoplastic Agents, Phytogenic, Humans, Viburnum