(Retz.) Sw.: Ethnomedicinal, Phytochemical, and Pharmacological Overview of the Himalayan Ferns.

Prabhakar Semwal, Sakshi Painuli, Kartik M Painuli, Gizem Antika, Tugba Boyunegmez Tumer, Ashish Thapliyal, William N Setzer, Miquel Martorell, Mohammed M Alshehri, Yasaman Taheri, Sevgi Durna Daştan, Seyed Abdulmajid Ayatollahi, Anka Trajkovska Petkoska, Javad Sharifi-Rad, William C Cho

Journal: Oxidative medicine and cellular longevity 2022;2021():1917890

PMID: 34512863

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Abstract

The genus (family: Athyriaceae) comprises approximately 350 species of pteridophytes (Retz.) Sw. is an important member of this genus and commonly known as a wild vegetable in the Himalayan and sub-Himalayan communities. According to the literature analysis, was traditionally used for the prevention or treatment of several diseases such as diabetes, smallpox, asthma, diarrhea, rheumatism, dysentery, headache, fever, wounds, pain, measles, hypertension, constipation, oligospermia, bone fracture, and glandular swellings. Various extracts of were evaluated to elucidate their phytochemical and pharmacological activities. A wide array of pharmacological properties such as antioxidant, antimicrobial, antidiabetic, immunomodulatory, CNS stimulant, and antianaphylactic activities have been recognized in different parts of . The review covers a systematic examination of pharmacognosy, phytochemistry, and pharmacological applications of , but scientifically, it is not fully assessed regarding complete therapeutic effects, toxicity, and safety in the human body. The published literature on and its therapeutic properties were collected from different search engines including Wiley online, PubMed, Springer Link, Scopus, Science Direct, Web of Science, Google Scholar, and ACS publications by using specific terms such as " bioactive compounds, biological activities and health benefits" from 1984 to 2021 (March). Therefore, further studies are required to identify the detailed action mechanism of , and also, more studies should focus on conservation, cultivation, and sustainable utilization of the species.

Address: Department of Biotechnology, Graphic Era University, Dehradun, Uttarakhand, India.; Uttarakhand State Council for Science and Technology, Dehradun, Uttarakhand, India.; Department of Biotechnology, Graphic Era University, Dehradun, Uttarakhand, India.; Himalayan Environmental Studies and Conservation Organization, Dehradun, Uttarakhand, India.; Uttarakhand Ayurved University, Gurukul Campus (Haridwar), Uttarakhand, India.; Graduate Program of Molecular Biology and Genetics, Institute of Natural and Applied Sciences, CanakkaleOnsekiz Mart University, Canakkale, Turkey.; Department of Molecular Biology and Genetics, Faculty of Arts and Science, CanakkaleOnsekiz Mart University, Canakkale, Turkey.; Department of Biotechnology, Graphic Era University, Dehradun, Uttarakhand, India.; Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA.; Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT 84043, USA.; Department of Nutrition and Dietetics, Faculty of Pharmacy, And Centre for Healthy Living, University of Concepción, 4070386 Concepción, Chile.; Pharmaceutical Care Department, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia.; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Biology, Faculty of Science, Sivas Cumhuriyet University, 58140 Sivas, Turkey.; Beekeeping Development Application and Research Center, Sivas Cumhuriyet University, 58140 Sivas, Turkey.; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Pharmacognosy and Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.; Faculty of Technology and Technical Sciences, St. Kliment Ohridski University-Bitola, Dimitar Vlahov, 1400 Veles, North Macedonia.; Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong.

DOI: 10.1155/2021/1917890

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MeSH Terms: Ferns, Humans, Medicine, Traditional, Phytochemicals